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Article

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo.

Nature genetics - 1 Mar 2003

Hemann Michael T, Fridman Jordan S, Zilfou Jack T, Hernando Eva, Paddison Patrick J, Cordon-Cardo Carlos, Hannon Gregory J, Lowe Scott W

Abstract excerpt

The application of RNA interference (RNAi) to mammalian systems has the potential to revolutionize genetics and produce novel therapies. Here we investigate whether RNAi applied to a well-characterized gene can stably suppress gene expression in hematopoietic stem cells and produce detectable phenotypes in mice. Deletion of the Trp53 tumor suppressor gene greatly accelerates Myc-induced lymphomagenesis, resulting...

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Source

Identifiers

PMID: 12567186
DOI: 10.1038/ng1091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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