Article
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
Cell - 17 Dec 2004
Lang Gene A, Iwakuma Tomoo, Suh Young-Ah, Liu Geng, Rao V Ashutosh, Parant John M, Valentin-Vega Yasmine A, Terzian Tamara, Caldwell Lisa C, Strong Louise C, El-Naggar Adel K, Lozano Guillermina
Abstract excerpt
Individuals with Li-Fraumeni syndrome carry inherited mutations in the p53 tumor suppressor gene and are predisposed to tumor development. To examine the mechanistic nature of these p53 missense mutations, we generated mice harboring a G-to-A substitution at nucleotide 515 of p53 (p53+/515A) corresponding to the p53R175H hot spot mutation in human cancers. Although p53+/515A mice display a similar tumor spectrum...
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