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Article

Interaction of the oncogenic miR-21 microRNA and the p53 tumor suppressor pathway

5 Feb 2013

Abstract excerpt

MicroRNA-21 (miR-21) is overexpressed virtually in all human cancers and displays oncogenic activity in a transgenic murine model. Similarly, the p53 tumor suppressor gene is the most frequently mutated gene in human cancer, and its loss or mutation leads to tumor formation in mice. To ascertain the role of miR-21 in the p53 pathway in vivo and to characterize their interaction in tumorigenesis, we intercrossed...

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PMID: 23385064
DOI: 10.1093/carcin/bgt044

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