Article

The p53-p21 axis plays a central role in lymphatic homeostasis and disease

2020-03-20

Abstract excerpt

Activation of the transcription factor p53 has been associated with several developmental syndromes. In normal tissues, p53 is kept at very low undetectable physiological levels. When triggered by cellular stressors, p53 prompts important anti-proliferative and apoptotic programs part of its tumor suppressor activity or as the guardian of tissue homeostasis. We generated two murine models that display cutaneous he...

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Literature Corpus work: 8cd9c145-9ad6-5429-b316-4f494c093871
DOI: 10.1101/2020.03.18.992784

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