Article

Glioblastoma-infiltrating CD8 <sup>+</sup> T cells are predominantly a clonally expanded <i>GZMK</i> <sup>+</sup> effector population

2023-08-27

Abstract excerpt

Recent clinical trials have highlighted the limited efficacy of T cell-based immunotherapy in patients with glioblastoma (GBM). To better understand the characteristics of tumor-infiltrating lymphocytes (TIL) in GBM, we performed cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) and single-cell RNA sequencing (scRNA-seq) with paired V(D)J sequencing, respectively, on TIL from two cohorts of...

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Literature Corpus work: 291ad562-b55a-5e83-a7f0-022dea738879
DOI: 10.1101/2023.08.25.554678

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