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Glioblastoma-Infiltrating CD8 + T Cells Are Predominantly a Clonally Expanded GZMK + Effector Population

27 Feb 2024

Abstract excerpt

Recent clinical trials have highlighted the limited efficacy of T cell-based immunotherapy in patients with glioblastoma (GBM). To better understand the characteristics of tumor-infiltrating lymphocytes (TIL) in GBM, we performed cellular indexing of transcriptomes and epitopes by sequencing and single-cell RNA sequencing with paired V(D)J sequencing, respectively, on TILs from two cohorts of patients totaling 15...

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PMID: 38416133
DOI: 10.1158/2159-8290.cd-23-0913

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