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The glioblastoma multiforme tumor site promotes the commitment of tumor-infiltrating lymphocytes to the T H 17 lineage in humans

15 Aug 2022

Abstract excerpt

Although glioblastoma multiforme (GBM) is not an invariably cold tumor, checkpoint inhibition has largely failed in GBM. In order to investigate T cell–intrinsic properties that contribute to the resistance of GBM to endogenous or therapeutically enhanced adaptive immune responses, we sorted CD4 + and CD8 + T cells from the peripheral blood, normal-appearing brain tissue, and tumor bed of nine treatment-naive...

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PMID: 35969754
DOI: 10.1073/pnas.2206208119

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