Article
Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered NK cell phenotype in glioblastoma.
Clinical and experimental immunology - 1 Apr 2020
Close H J, Stead L F, Nsengimana J, Reilly K A, Droop A, Wurdak H, Mathew R K, Corns R, Newton-Bishop J, Melcher A A, Short S C, Cook G P, Wilson E B
Abstract excerpt
Glioblastoma (GBM) is an aggressive cancer with a very poor prognosis. Generally viewed as weakly immunogenic, GBM responds poorly to current immunotherapies. To understand this problem more clearly we used a combination of natural killer (NK) cell functional assays together with gene and protein expression profiling to define the NK cell response to GBM and explore immunosuppression in the GBM microenvironment....
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