Article
Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered NK cell phenotype in glioblastoma.
Clinical and experimental immunology - 1 Apr 2020
Close H J, Stead L F, Nsengimana J, Reilly K A, Droop A, Wurdak H, Mathew R K, Corns R, Newton-Bishop J, Melcher A A, Short S C, Cook G P, Wilson E B
Abstract excerpt
Glioblastoma (GBM) is an aggressive cancer with a very poor prognosis. Generally viewed as weakly immunogenic, GBM responds poorly to current immunotherapies. To understand this problem more clearly we used a combination of natural killer (NK) cell functional assays together with gene and protein expression profiling to define the NK cell response to GBM and explore immunosuppression in the GBM microenvironment....
Topics
- Brain Neoplasms
- Cell Line, Tumor
- Cells, Cultured
- Cohort Studies
- Cytotoxicity, Immunologic
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Gene Regulatory Networks
- Glioblastoma