Article

Thymidylate synthase disruption to limit cell proliferation in cell therapies

2023-06-26

Abstract excerpt

Engineered cells hold great promise for regenerative medicine and gene therapy. However, living cell products entail a fundamental biological risk of unwanted growth. Here, we describe a novel metabolic safety system to control cell proliferation without added genetic elements. We inactivated a key enzyme for nucleotide metabolism, TYMS , in several cell lines, thus obtaining cells that proliferate only when supp...

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Literature Corpus work: 28f1b30d-4a61-5425-a162-25b53c8aea1a
DOI: 10.1101/2023.06.26.546441

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