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CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs

5 Jan 2023

Abstract excerpt

BACKGROUND: Transplantation of differentiated cells from human-induced pluripotent stem cells (hiPSCs) holds great promise for clinical treatments. Eliminating the risk factor of malignant cell transformation is essential for ensuring the safety of such cells. This study was aimed at assessing and mitigating mutagenicity that may arise during the cell culture process in the protocol of pancreatic islet cell...

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PMID: 36600289
DOI: 10.1186/s13287-022-03220-4

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