Article

p16 <sup>High</sup> senescence restricts totipotent potential during somatic cell reprogramming

2022-08-25

Abstract excerpt

The discovery of four factor (4F)-induced reprogramming of somatic cells into induced pluripotent stem (iPS) cells has revolutionized the fields of cell and regenerative biology. In contrast, the feasibility of a direct conversion of somatic cells into a totipotent state defined as the ability to produce all cell types of an organism, including extraembryonic tissues, is not well established. Using genetic and che...

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Literature Corpus work: 30a74817-adc6-5d04-9994-a8e1f6ad84f5
DOI: 10.1101/2022.08.24.504108

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