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Thymidylate synthase disruption to limit cell proliferation in cell therapies

12 Jun 2024

Abstract excerpt

Stem and progenitor cells hold great promise for regenerative medicine and gene therapy approaches. However, transplantations of living cells entail a fundamental risk of unwanted growth, potentially exacerbated by CRISPR-Cas9 or other genetic manipulations. Here, we describe a safety system to control cell proliferation while allowing robust and efficient cell manufacture, without any added genetic elements....

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PMID: 38867450
DOI: 10.1016/j.ymthe.2024.06.014

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