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Reduced replication fork speed promotes pancreatic endocrine differentiation and controls graft size

2 Feb 2021

Abstract excerpt

Limitations in cell proliferation are important for normal function of differentiated tissues and essential for the safety of cell replacement products made from pluripotent stem cells, which have unlimited proliferative potential. To evaluate whether these limitations can be established pharmacologically, we exposed pancreatic progenitors differentiating from human pluripotent stem cells to small molecules that...

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PMID: 33529174
DOI: 10.1172/jci.insight.141553

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