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Article

Targeted killing of a mammalian cell based upon its specialized metabolic state

6 Sept 2011

Abstract excerpt

Mouse ES cells use a mitochondrial threonine dehydrogenase (TDH) enzyme to catabolize threonine into glycine and acetyl-CoA. Measurements of mRNA abundance have given evidence that ES cells express upwards of 1,000-fold higher levels of TDH mRNA than any of seven other mouse tissues tested. When cell culture medium is deprived of threonine, ES cells rapidly discontinue DNA synthesis, arrest cell division, and...

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PMID: 21896756
DOI: 10.1073/pnas.1111312108

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