Article
Feasibility and application of polygenic score analysis to the morphology of human induced pluripotent stem cells
2020-12-11
Abstract excerpt
Genome-wide association studies have identified thousands of significant associations between genetic variants and complex traits. Inferring biological insights from these associations has been challenging. One approach attempted has been to examine the effects of individual variants in cellular models. Here, I demonstrate the feasibility of examining the aggregate effect of many variants on cellular phenotypes. I...
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Identifiers and source
- Literature Corpus work
- 28f1aa21-501a-5cd2-a176-d19461f67c90
- DOI
- 10.1101/2020.12.11.411314