Feasibility and application of polygenic score analysis to the morphology of human-induced pluripotent stem cells.

Abstract excerpt

Genome-wide association studies have identified thousands of significant associations between genetic variants and complex traits. Inferring biological insights from these associations has been challenging. One approach attempted has been to examine the effects of individual variants in cellular models. Here, I demonstrate the feasibility of examining the aggregate effect of many variants on cellular phenotypes....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Feasibility Studies
• Share to Genetic Predisposition to Disease