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Bridging population and cell: modelling complex diseases with human induced pluripotent stem cells.

European journal of human genetics : EJHG - 1 Jun 2026

van Zanten Eva S, Loehrer Elizabeth A, van Meurs Joyce B J, Narcisi Roberto, Gribnau Joost H, Poot Raymond A, Adams Hieab H H

Abstract excerpt

Induced pluripotent stem cells (iPSCs) have emerged as a powerful tool in biomedical research, enabling the study of cellular function and early disease mechanisms within patient-specific genetic contexts. Traditionally, iPSCs have been used to model monogenic diseases, where highly penetrant variants produce robust cellular phenotypes detectable in few cell lines. Recent advances in scalability and...

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PMID: 41917264
DOI: 10.1038/s41431-026-02071-4
PMCID: PMC13247087

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