Integrating population genetics, stem cell biology and cellular genomics to study complex human diseases.

Abstract excerpt

Human pluripotent stem (hPS) cells can, in theory, be differentiated into any cell type, making them a powerful in vitro model for human biology. Recent technological advances have facilitated large-scale hPS cell studies that allow investigation of the genetic regulation of molecular phenotypes and their contribution to high-order phenotypes such as human disease. Integrating hPS cells with single-cell...

Topics

• Humans
• Disease
• Genetic Variation
• Genetics, Population
• Genomics
• Phenotype
• Pluripotent Stem Cells
• Single-Cell Analysis