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Article

Investigating monogenic and complex diseases with pluripotent stem cells.

Nature reviews. Genetics - 1 Apr 2011

Zhu Hao, Lensch M William, Cahan Patrick, Daley George Q

Abstract excerpt

Human genetic studies have revealed the molecular basis of countless monogenic diseases but have been less successful in associating phenotype to genotype in complex multigenic conditions. Pluripotent stem cells (PSCs), which can differentiate into any cell type, offer promise for defining the functional effects of genetic variation. Here, we recount the advantages and practical limitations of coupling PSCs to...

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PMID: 21386866
DOI: 10.1038/nrg2951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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