Article

Anti-prion drugs do not improve survival in knock-in models of inherited prion disease

2023-09-29

Abstract excerpt

Prion diseases uniquely manifest in three distinct forms: inherited, sporadic, and infectious. Wild-type prions are responsible for the sporadic and infectious versions, while mutant prions cause inherited variants like fatal familial insomnia (FFI) and familial Creutzfeldt-Jakob disease (fCJD). Although some drugs can prolong prion incubation times up to four-fold in rodent models of infectious prion diseases, no...

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Literature Corpus work: 28da05a7-a461-5013-9486-e0b000292c8d
DOI: 10.1101/2023.09.28.559951

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