Article

Analysis of non-human primate models for evaluating prion disease therapeutic efficacy

2022-04-07

Abstract excerpt

<h4>ABSTRACT</h4> Prion disease is a fatal neurodegenerative disease caused by the conformational corruption of the prion protein (PrP), encoded by the prion protein gene ( PRNP ). While no disease-modifying therapy is currently available, genetic and pharmacological proofs of concept support development of therapies that lower PrP levels in the brain. In light of proposals for clinical testing of such drugs in...

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Literature Corpus work: 5b4e53cb-d51e-5bf0-8ef5-201adf30e8cc
DOI: 10.1101/2022.03.22.485331

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