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Article

Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases.

Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 2013

Jackson Walker S, Borkowski Andrew W, Watson Nicki E, King Oliver D, Faas Henryk, Jasanoff Alan, Lindquist Susan

Abstract excerpt

In man, mutations in different regions of the prion protein (PrP) are associated with infectious neurodegenerative diseases that have remarkably different clinical signs and neuropathological lesions. To explore the roots of this phenomenon, we created a knock-in mouse model carrying the mutation...

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Identifiers

PMID: 23959875
DOI: 10.1073/pnas.1312006110
PMCID: PMC3767526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23959875-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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