Article
In vitro screen of prion disease susceptibility genes using the scrapie cell assay.
Human molecular genetics - 1 Oct 2014
Brown Craig A, Schmidt Christian, Poulter Mark, Hummerich Holger, Klöhn Peter-C, Jat Parmjit, Mead Simon, Collinge John, Lloyd Sarah E
Abstract excerpt
Prion diseases (transmissible spongiform encephalopathies) are fatal neurodegenerative diseases, including Creutzfeldt-Jakob disease in humans, scrapie in sheep and bovine spongiform encephalopathy in cattle. While genome-wide association studies in human and quantitative trait loci mapping in mice have provided evidence for multiple susceptibility genes, few of these have been confirmed functionally. Phenotyping...
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