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Article

Strain Typing of Prion Diseases Using In Vivo Mouse Models.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Boyle Aileen, Hogan Kris, Manson Jean C, Diack Abigail B

Abstract excerpt

Transmissible spongiform encephalopathies (TSE) or prion diseases exhibit strain variation, a phenomenon that has been studied extensively in mouse bioassays. Despite the introduction of many rapid in vitro systems, bioassays remain a key tool in defining prion strains and their ability to transmit disease in vivo. Prion strains can be characterized by a range of phenotypic characteristics such as incubation...

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PMID: 28861795
DOI: 10.1007/978-1-4939-7244-9_18

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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