Article
Novel Allele Detection Tool Benchmark and Application With Antibody Repertoire Sequencing Dataset.
Frontiers in immunology - 1 Jan 2021
Yang Xiujia, Zhu Yan, Chen Sen, Zeng Huikun, Guan Junjie, Wang Qilong, Lan Chunhong, Sun Deqiang, Yu Xueqing, Zhang Zhenhai
Abstract excerpt
Detailed knowledge of the diverse immunoglobulin germline genes is critical for the study of humoral immunity. Hundreds of alleles have been discovered by analyzing antibody repertoire sequencing (Rep-seq or Ig-seq) data via multiple novel allele detection tools (NADTs). However, the performance of these NADTs through antibody sequences with intrinsic somatic hypermutations (SHMs) is unclear. Here, we developed a...
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