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Per-sample immunoglobulin germline inference from B cell receptor deep sequencing data

22 Jul 2019

Abstract excerpt

The collection of immunoglobulin genes in an individual's germline, which gives rise to B cell receptors via recombination, is known to vary significantly across individuals. In humans, for example, each individual has only a fraction of the several hundred known V alleles. Furthermore, the currently-accepted set of known V alleles is both incomplete (particularly for non-European samples), and contains a...

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PMID: 31329576
DOI: 10.1371/journal.pcbi.1007133

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