Article

APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response

2017-04-04

Abstract excerpt

<h4>Background</h4> The APOBEC family of enzymes is responsible for a mutation signature characterized by a TCW>T/G mutation. APOBEC-mediated mutagenesis is implicated in a wide variety of tumors, including bladder cancer. In this study, we explore the APOBEC mutational signature in bladder cancer and the relationship with specific mutations, molecular subtype, gene expression, and survival. We hypothesized that...

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Literature Corpus work: abccbe77-7c8e-5058-85e2-7fe7f3cf0481
DOI: 10.1101/123802

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