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Dnmt3a-dependent <i>de novo</i> DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells

2024-12-06

Abstract excerpt

<h4>ABSTRACT</h4> Following acute viral infection, naïve CD4+ T cells differentiate into T follicular helper (Tfh) and T helper 1 (Th1) cells that generate long-lived memory cells. However, it is unclear how memory Tfh and Th1 cells maintain their lineage commitment. We demonstrate that Tfh and Th1 lineages acquire distinct Dnmt3a-dependent de novo DNA methylation programs that are preserved into memory. Dnmt3a...

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Identifiers and source

Literature Corpus work
28c26474-49ae-5463-b457-307cf4d60242
DOI
10.1101/2024.12.03.623450
Open publication

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Dnmt3a-dependent <i>de novo</i> DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cellsDOI 10.1101/2024.12.03.623450
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