Article
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling.
Cell stem cell - 5 Aug 2021
Hormaechea-Agulla Daniel, Matatall Katie A, Le Duy T, Kain Bailee, Long Xiaochen, Kus Pawel, Jaksik Roman, Challen Grant A, Kimmel Marek, King Katherine Y
Abstract excerpt
Age-related clonal hematopoiesis (CH) is a risk factor for malignancy, cardiovascular disease, and all-cause mortality. Somatic mutations in DNMT3A are drivers of CH, but decades may elapse between the acquisition of a mutation and CH, suggesting that environmental factors contribute to clonal expansion. We tested whether infection provides selective pressure favoring the expansion of Dnmt3a mutant hematopoietic...
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