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DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8 <sup>+</sup> T cells

2023-11-06

Abstract excerpt

<h4>ABSTRACT</h4> Epigenetic mechanisms stabilize gene expression patterns during CD8 + T cell differentiation. However, although adoptive transfer of virus-specific T cells is clinically applied to reduce the risk of virus infection or reactivation in immunocompromised individuals, the DNA methylation pattern of virus-specific CD8 + T cells is largely unknown. Hence, we here performed whole-genome bisulfite se...

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Literature Corpus work
d242d177-cedc-5323-9cfa-01bf0be448bd
DOI
10.1101/2023.11.06.565829
Open publication

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DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8 <sup>+</sup> T cellsDOI 10.1101/2023.11.06.565829
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