Article
T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.
Immunity - 20 Oct 2015
Cook Kevin D, Shpargel Karl B, Starmer Joshua, Whitfield-Larry Fatima, Conley Bridget, Allard Denise E, Rager Julia E, Fry Rebecca C, Davenport Marsha L, Magnuson Terry, Whitmire Jason K, Su Maureen A
Abstract excerpt
Epigenetic changes, including histone methylation, control T cell differentiation and memory formation, though the enzymes that mediate these processes are not clear. We show that UTX, a histone H3 lysine 27 (H3K27) demethylase, supports T follicular helper (Tfh) cell responses that are essential for B cell antibody generation and the resolution of chronic viral infections. Mice with a T cell-specific UTX...
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