Passenger mutations can accelerate tumor suppressor gene inactivation in cancer evolution

Abstract excerpt

Carcinogenesis is an evolutionary process whereby cells accumulate multiple mutations. Besides the “driver mutations” that cause the disease, cells also accumulate a number of other mutations with seemingly no direct role in this evolutionary process. They are called passenger mutations. While it has been argued that passenger mutations render tumors more fragile due to reduced fitness, the role of passenger mutat...

Topics

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• Computer Simulation
• Disease Progression
• Evolution, Molecular
• Genes, Tumor Suppressor
• Models, Biological
• Models, Genetic
• Mutation
• Neoplasms

Identifiers and source

Literature Corpus work

4bd97822-737c-5837-ab05-f1313200da0b

DOI

10.1101/202531