Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Associations of Alzheimer’s disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration

8 Jan 2021

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified more than 30 Alzheimer's disease (AD) risk genes, although the detailed mechanism through which all these genes are associated with AD pathogenesis remains unknown. We comprehensively evaluate the roles of the variants in top 30 non-APOE AD risk genes, based on whether these variants were associated with altered mRNA transcript levels, as well as brain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Dementia and Cognitive Impairment Research
Share to Genetic Associations and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33419465
DOI: 10.1186/s13195-020-00755-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Associations of Alzheimer’s disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegenerationPMID 33419465Read ↗

Brain Region-Dependent Alternative Splicing of Alzheimer Disease (AD)-Risk Genes Is Associated With Neuropathological Features in ADSemantic proximity Read ↗

Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s diseaseSemantic proximity Read ↗

Whole exome sequencing analyses identified novel genes for Alzheimer's disease and related dementia.Semantic proximity Read ↗

Identification of common molecular biomarker signatures in blood and brain of Alzheimer’s diseaseSemantic proximity Read ↗

Alzheimer's disease risk genes and mechanisms of disease pathogenesis.Semantic proximity Read ↗

Genes associated with Alzheimer's disease: an overview and current status.Semantic proximity Read ↗

Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.Semantic proximity Read ↗

Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics.Semantic proximity Read ↗

Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis.Semantic proximity Read ↗

Transcriptome-wide association study of Alzheimer disease reveals many differentially expressed genes and multiple biological pathways in brain tissue from African American donorsSemantic proximity Read ↗

Alzheimer's Disease Investigated via Gene-Environment Interactions, Biochemical Pathways, Cellular Processes, and Disease Phenotype VariabilitySemantic proximity Read ↗

New insights on the genetic etiology of Alzheimer’s and related dementiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.