Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models.

Stem cell reports - 13 Aug 2024

Gomes Cátia, Huang Kang-Chieh, Harkin Jade, Baker Aaron, Hughes Jason M, Pan Yanling, Tutrow Kaylee, VanderWall Kirstin B, Lavekar Sailee S, Hernandez Melody, Cummins Theodore R, Canfield Scott G, Meyer Jason S

Abstract excerpt

Reactive astrocytes are known to exert detrimental effects upon neurons in several neurodegenerative diseases, yet our understanding of how astrocytes promote neurotoxicity remains incomplete, especially in human systems. In this study, we leveraged human pluripotent stem cell (hPSC) models to examine how reactivity alters astrocyte function and mediates neurodegeneration. hPSC-derived astrocytes were induced to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Blood-Brain Barrier

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coculture Techniques

Share to Complement C3

Share to Glaucoma

Share to Neurodegenerative Diseases

Share to Phagocytosis

Share to Pluripotent Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 39094561
DOI: 10.1016/j.stemcr.2024.07.002
PMCID: PMC11368677

Genes

C3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models.PMID 39094561Read ↗

Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discoverySemantic proximity Read ↗

hiPSC-derived astrocytes from individuals with schizophrenia induce a dystrophic phenotype in microglial-like cellsSemantic proximity Read ↗

An efficient platform for astrocyte differentiation from human induced pluripotent stem cellsSemantic proximity Read ↗

hiPSC-Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial-Like Cells.Semantic proximity Read ↗

Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system.Semantic proximity Read ↗

Non-cell autonomous astrocyte-mediated neuronal toxicity in prion diseasesSemantic proximity Read ↗

Varicose-projection astrocytes: a reactive phenotype associated with neuropathologySemantic proximity Read ↗

Neurodegenerative Diseases: Unraveling the Heterogeneity of Astrocytes.Semantic proximity Read ↗

Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies.Semantic proximity Read ↗

Functional roles of reactive astrocytes in neuroinflammation and neurodegenerationSemantic proximity Read ↗

Senescent and reactive astrocytes display distinct expression profiles and divergent functional capacities.Semantic proximity Read ↗

Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.