Article

Deconvolution of cellular subsets in human tissue based on targeted DNA methylation analysis at individual CpG sites

2020-07-29

Abstract excerpt

<h4>Background</h4> The complex composition of different cell types within a tissue can be estimated by deconvolution of omics datasets. For example, DNA methylation (DNAm) profiles have been used to establish an atlas for multiple human tissues and cell types. In this study, we investigated if deconvolution is also feasible with individual cell-type-specific CG dinucleotides (CpG sites), which can be addressed b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 289ff2a3-490a-5608-903a-e6a016bbd60b
DOI: 10.1101/2020.07.28.225185

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deconvolution of cellular subsets in human tissue based on targeted DNA methylation analysis at individual CpG sitesDOI 10.1101/2020.07.28.225185Read

Multi-cell type deconvolution using a probabilistic model for single-molecule DNA methylation haplotypesSemantic proximity Read

A human DNA methylation atlas reveals principles of cell type-specific methylation and identifies thousands of cell type-specific regulatory elementsSemantic proximity Read

Systematic Evaluation of Cell Type Deconvolution Methods for Plasma Cell-free DNASemantic proximity Read

scMD: cell type deconvolution using single-cell DNA methylation referencesSemantic proximity Read

A Cell Type Enrichment Analysis Tool for Brain DNA Methylation Data (CEAM)Semantic proximity Read

Benchmarking of Methods for DNA Methylome DeconvolutionSemantic proximity Read

Deconvolution-based cell-type specific DNA methylation-wide and transcriptome-wide association studies identify risk CpG sites and genes associated with colorectal cancer riskSemantic proximity Read

Cell-type deconvolution in epigenome-wide association studies: a review and recommendations.Semantic proximity Read

Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGARSemantic proximity Read

A Novel Cell-Type Deconvolution Algorithm Reveals Substantial Contamination by Immune Cells in Saliva, Buccal and CervixSemantic proximity Read

Mapping the landscape of cell type-dependent genetic regulation of DNA methylation across human tissuesSemantic proximity Read

cfDecon: Accurate and Interpretable methylation-based cell type deconvolution for cell-free DNASemantic proximity Read