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Article

A Novel Cell-Type Deconvolution Algorithm Reveals Substantial Contamination by Immune Cells in Saliva, Buccal and Cervix

25 Apr 2018

Abstract excerpt

AIM: An outstanding challenge in epigenome studies is the estimation of cell-type proportions in complex epithelial tissues. MATERIALS & METHODS: Here, we construct and validate a DNA methylation reference and algorithm for complex tissues that contain epithelial, immune and nonimmune stromal cells. RESULTS: Using this reference, we show that easily accessible tissues such as saliva, buccal and cervix exhibit...

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Share to Epigenetics and DNA Methylation
Share to Salivary Gland Disorders and Functions
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PMID: 29693419
DOI: 10.2217/epi-2018-0037

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