Article

Removing genetic effects on plasma proteins enhances their utility as disease biomarkers

2025-10-15

Abstract excerpt

Plasma protein levels are influenced by both genetic and non-genetic factors and can serve as early disease biomarkers. When a protein is correlated with, but not causally linked to, disease, its genetic determinants can add unwanted variability to protein–disease associations. In such cases, removing the genetic component may improve their predictive performances. Here, we tested this hypothesis by genetically ad...

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Literature Corpus work: 3562f48f-db99-5200-92e1-4da38d1c068e
DOI: 10.1101/2025.10.14.25337894

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