Article
Disease prediction with multi-omics and biomarkers empowers case-control genetic discoveries in the UK Biobank.
Nature genetics - 1 Sept 2024
Garg Manik, Karpinski Marcin, Matelska Dorota, Middleton Lawrence, Burren Oliver S, Hu Fengyuan, Wheeler Eleanor, Smith Katherine R, Fabre Margarete A, Mitchell Jonathan, O'Neill Amanda, Ashley Euan A, Harper Andrew R, Wang Quanli, Dhindsa Ryan S, Petrovski Slavé, Vitsios Dimitrios
Abstract excerpt
The emergence of biobank-level datasets offers new opportunities to discover novel biomarkers and develop predictive algorithms for human disease. Here, we present an ensemble machine-learning framework (machine learning with phenotype associations, MILTON) utilizing a range of biomarkers to predict 3,213 diseases in the UK Biobank. Leveraging the UK Biobank's longitudinal health record data, MILTON predicts...
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