Article

Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity

2023-02-15

Abstract excerpt

<h4>ABSTRACT</h4> Durable serological memory following vaccination is critically dependent on the production and survival of long-lived plasma cells (LLPCs). Yet, the factors that control LLPC specification and survival remain poorly resolved. Using intra-vital two-photon imaging, we find that in contrast to most plasma cells in the bone marrow (BM), LLPCs are uniquely sessile and organized into clusters that are...

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Literature Corpus work: c51b90d3-b94d-52e7-802b-ccf377a45cae
DOI: 10.1101/2023.02.15.527913

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