Article

Tumor reactivity assessment using clonal expression (TRACE) reveals tumor reactive CD8 <sup>+</sup> T cell heterogeneity across solid tumors

2026-02-26

Abstract excerpt

1 <h4>Introduction</h4> Tumor infiltrating lymphocytes (TIL) drive the anti-tumor activity of a broad class of immunotherapies. In situ TIL are composed of T cells that recognize tumor antigens (Tumor Reactive T cells, or TRTs) as well as bystander T cells with specificity for other antigens. TRT clonotypes are associated with a unique and tumor-driven exhausted transcriptional state, enabling single-cell RNA se...

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Literature Corpus work: 030cbd58-8012-5928-9718-6d7b6bf66cb0
DOI: 10.64898/2026.02.25.707942

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