Article

Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

2020-10-01

Abstract excerpt

The ability to monitor anti-tumor CD8 + T cell responses in the blood has tremendous therapeutic potential. Here, we used paired single-cell RNA sequencing and T cell receptor (TCR) sequencing to detect and characterize “tumor matching” (TM) CD8 + T cells in the blood of mice with MC38 tumors and melanoma patients using the TCR as a molecular barcode. TM cells showed increased activation compared to non-matching...

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Literature Corpus work: e163941a-5936-5283-ba43-880a4548ae50
DOI: 10.1101/2020.09.30.294959

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