Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates.

doi:10.1038/s41586-018-0130-2

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Article

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates.

Nature - 1 May 2018

Simoni Yannick, Becht Etienne, Fehlings Michael, Loh Chiew Yee, Koo Si-Lin, Teng Karen Wei Weng, Yeong Joe Poh Sheng, Nahar Rahul, Zhang Tong, Kared Hassen, Duan Kaibo, Ang Nicholas, Poidinger Michael, Lee Yin Yeng, Larbi Anis, Khng Alexis J, Tan Emile, Fu Cherylin, Mathew Ronnie, Teo Melissa, Lim Wan Teck, Toh Chee Keong, Ong Boon-Hean, Koh Tina, Hillmer Axel M, Takano Angela, Lim Tony Kiat Hon, Tan Eng Huat, Zhai Weiwei, Tan Daniel S W, Tan Iain Beehuat, Newell Evan W

Abstract excerpt

Various forms of immunotherapy, such as checkpoint blockade immunotherapy, are proving to be effective at restoring T cell-mediated immune responses that can lead to marked and sustained clinical responses, but only in some patients and cancer types1-4. Patients and tumours may respond unpredictably to immunotherapy partly owing to heterogeneity of the immune composition and phenotypic profiles of...

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PMID: 29769722
DOI: 10.1038/s41586-018-0130-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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