Article

CD39 Identifies Tumor-Reactive CD8 T cells in Patients With Lung Cancer

2022-01-27

Abstract excerpt

<h4>ABSTRACT</h4> The repertoire of tumor-infiltrating lymphocytes (TILs) can be vast, and many of these TILs are not endowed with tumor reactivity. While a number of reports have shown that tumor-reactive TILs express CD39, few reports have demonstrated that conversely, CD39 can be leveraged to serve as a proxy of tumor-reactive CD8 T cells. Using single-cell CITE/RNA/TCRseq, we show that CD39 + CD8 T cells in...

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Literature Corpus work: 87380ba5-37c5-5df5-82e1-d8d4468a1b46
DOI: 10.1101/2022.01.24.477554

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