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Article

Cardiac myosin binding protein C: its role in physiology and disease.

Circulation research - 28 May 2004

Flashman Emily, Redwood Charles, Moolman-Smook Johanna, Watkins Hugh

Abstract excerpt

Myosin binding protein-C (MyBP-C) is a thick filament-associated protein localized to the crossbridge-containing C zones of striated muscle sarcomeres. The cardiac isoform is composed of eight immunoglobulin I-like domains and three fibronectin 3-like domains and is known to be a physiological substrate of cAMP-dependent protein kinase. MyBP-C contributes to thick filament structure via interactions at its...

Topics

Cardiomyopathy, Hypertrophic
Carrier Proteins
Humans
Models, Molecular
Mutation
Myocardial Contraction
Sarcomeres

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 15166115
DOI: 10.1161/01.RES.0000127175.21818.C2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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