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Article

The cMyBP-C HCM variant L348P enhances thin filament activation through an increased shift in tropomyosin position.

Journal of molecular and cellular cardiology - 1 Feb 2016

Mun Ji Young, Kensler Robert W, Harris Samantha P, Craig Roger

Abstract excerpt

Mutations in cardiac myosin binding protein C (cMyBP-C), a thick filament protein that modulates contraction of the heart, are a leading cause of hypertrophic cardiomyopathy (HCM). Electron microscopy and 3D reconstruction of thin filaments decorated with cMyBP-C N-terminal fragments suggest that one mechanism of this modulation involves the interaction of cMyBP-C's N-terminal domains with thin filaments to...

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Identifiers

PMID: 26718724
DOI: 10.1016/j.yjmcc.2015.12.014
PMCID: PMC4764391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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