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Article

Human cardiac myosin-binding protein C phosphorylation- and mutation-dependent structural dynamics monitored by time-resolved FRET.

Journal of molecular and cellular cardiology - 1 May 2022

Kanassatega Rhye-Samuel, Bunch Thomas A, Lepak Victoria C, Wang Christopher, Colson Brett A

Abstract excerpt

Cardiac myosin-binding protein C (cMyBP-C) is a thick filament-associated protein of the sarcomere and a potential therapeutic target for treating contractile dysfunction in heart failure. Mimicking the structural dynamics of phosphorylated cMyBP-C by small-molecule drug binding could lead to therapies that modulate cMyBP-C conformational states, and thereby function, to improve contractility. We have developed a...

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Identifiers

PMID: 35227736
DOI: 10.1016/j.yjmcc.2022.02.005
PMCID: PMC9067379

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