Article
Phosphorylation of cardiac Myosin-binding protein-C is a critical mediator of diastolic function.
Circulation. Heart failure - 1 May 2015
Rosas Paola C, Liu Yang, Abdalla Mohamed I, Thomas Candice M, Kidwell David T, Dusio Giuseppina F, Mukhopadhyay Dhriti, Kumar Rajesh, Baker Kenneth M, Mitchell Brett M, Powers Patricia A, Fitzsimons Daniel P, Patel Bindiya G, Warren Chad M, Solaro R John, Moss Richard L, Tong Carl W
Abstract excerpt
BACKGROUND: Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for ≈50% of all cases of HF and currently has no effective treatment. Diastolic dysfunction underlies HFpEF; therefore, elucidation of the mechanisms that mediate relaxation can provide new potential targets for treatment. Cardiac myosin-binding protein-C (cMyBP-C) is a thick filament protein that modulates cross-bridge cycling rates...
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