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Article

Actin-Myosin Interaction: Structure, Function and Drug Discovery.

International journal of molecular sciences - 5 Sept 2018

Guhathakurta Piyali, Prochniewicz Ewa, Thomas David D

Abstract excerpt

Actin-myosin interactions play crucial roles in the generation of cellular force and movement. The molecular mechanism involves structural transitions at the interface between actin and myosin's catalytic domain, and within myosin's light chain domain, which contains binding sites for essential (ELC) and regulatory light chains (RLC). High-resolution crystal structures of isolated actin and myosin, along with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30189615
DOI: 10.3390/ijms19092628
PMCID: PMC6163256

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