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Article

H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers.

eLife - 22 Jun 2018

Fang Dong, Gan Haiyun, Cheng Liang, Lee Jeong-Heon, Zhou Hui, Sarkaria Jann N, Daniels David J, Zhang Zhiguo

Abstract excerpt

Expression of histone H3.3K27M mutant proteins in human diffuse intrinsic pontine glioma (DIPG) results in a global reduction of tri-methylation of H3K27 (H3K27me3), and paradoxically, H3K27me3 peaks remain at hundreds of genomic loci, a dichotomous change that lacks mechanistic insights. Here, we show that the PRC2 complex is sequestered at poised enhancers, but not at active promoters with high levels of...

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Identifiers

PMID: 29932419
DOI: 10.7554/eLife.36696
PMCID: PMC6033537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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