Article

Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulation

2021-07-20

Abstract excerpt

Sex differences in physiology and disease in mammals result from the effects of three classes of factors that are inherently unequal in males and females: reversible (activational) effects of gonadal hormones, permanent (organizational) effects of gonadal hormones, and cell-autonomous effects of sex chromosomes, as well as genes driven by these classes of factors. Often, these factors act together to cause sex dif...

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Literature Corpus work: 28508f4f-1bf6-5b11-832a-10c07c22561c
DOI: 10.1101/2021.07.18.451543

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